Several drugs that reverse the blood thinning effect of non-vitamin K oral anticoagulants (NOAC) have arrived in the global market, but it will take some time for Korean physicians to use them, experts said. Representative NOAC reversal agents are used against Pradaxa (ingredient: dabigatran), Eliquis (apixaban), and Xarelto (rivaroxaban). The NOAC market has expanded rapidly as NOACs lowered the bleeding risk in stroke prevention treatment for atrial fibrillation patients, compared to warfarin....
Product information on treatment with PRAXBIND, the ONLY FDA-approved specific reversal agent for a NOAC available in all 50 states. Adverse reactions may occur with PRAXBIND. View Important Safety Information and Full Prescribing Information on website.
Boehringer Ingelheim announces its global RE-VECTO program for Praxbind® (idarucizumab), the specific reversal agent for Pradaxa® (dabigatran etexilate).[1,2] Praxbind® is approved to reverse the a...
Pradaxa (dabigatran) is a brand-name drug used to decrease your risk of developing a blood clot. Learn about side effects, dosage, reversal of bleeds, and more.
Background ; Brand name Pradaxa · If aPTT is <1.5 x control, it is unlikely that significant drug effect is present · Thrombin Time (TT) is most sensitive; normal TT excludes presence of significant dabigatran
WARNING: (A) PREMATURE DISCONTINUATION OF PRADAXA INCREASES THE RISK OF THROMBOTIC EVENTS, (B) SPINAL/EPIDURAL HEMATOMA (A) PREMATURE DISCONTINUATION OF PRADAXA INCREASES THE RISK OF...
한국베링거인겔하임㈜(대표이사: 박기환)은 자사의 항응고제 프라닥사 ; (성분명: 다비가트란에텍실레이트)의 역전제 프락스바인드Ⓡ(성분명: 이다루시주맙)가 6월 1일 국내에 출시했다고 밝혔다.
Anticoagulant, Half-life, Removed by HD, Strategies to reverse or minimize anticoagulant effects ; Apixaban [1] (Eliquis®), 8-15 hrs (longer in renal impairment), No, If ingested within 2 hours, administer activated charcoal 4-factor PCC (Kcentra™)^ 25units/kg—max 2500 units for treatment of documented intracranial hemorrhage 50 units/kg—max 5000 units for all other life-threatening bleeds ; Edoxaban [2] (Savaysa®), 10-14 hrs (longer in renal impairment), ~ 25%, As above ; Rivaroxaban [3] (Xarelto®), 9-13 hrs (longer in renal impairment), No, As above ; Fondaparinux (Arixtra®), 17-21 hrs (significantly longer in renal impairment), No, 4-factor PCC (Kcentra™)^ 50 units/kg—max 5000 units
Summary: Dabigatran (Pradaxa) is a member of the relatively new class of antithrombotic drugs known as direct thrombin inhibitors (DTIs). It may supplant warfarin (Coumadin) in a number of applicat...
Objective:To evaluate the role of idarucizumab, a humanized monoclonal antibody fragment, as a specific reversal agent for the anticoagulant activity of dabigatran and to review the pharmacology, p...