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Urinary levels of triclosan and parabens are associated with aeroallergen and food sensitization. by Jessica H Savage, Elizabeth C Matsui, Robert A Wood, Corinne A Keet. The Journal of allergy and...
What is triclosan? ; Triclosan is part of other materials, including pesticides and textiles. It keeps these materials resistant to bacterial growth. Clothing, shoes, carpeting, furniture, toys and kitchenware all contain the ingredient. The FDA doesn’t regulate these products. Triclosan’s first use was as a pesticide in the 1960s. It’s now an ingredient in commercial and industrial equipment such as conveyor belts and HVAC coils. In residential and public access areas, it’s used in floo...
15 to 0.3%. While allergy to triclosan-based products is uncommon, several cases of contact dermatitis secondary to triclosan have been reported.
Affiliation 1 Johns Hopkins Division of Allergy and Clinical Immunology, Baltimore, MD 21224... triclosan; benzophenone-3; propyl, methyl, butyl, and ethyl parabens; and specific IgE levels...
저자, Marshall NB ; Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505;Biostatistics and Epidemiology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505 andVet Path Services, Inc., Mason 45040, Ohio [email protected]. Lukomska E ; Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505; Long CM ; Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505; Kashon ML ; Biostatistics and Epidemiology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505 and. Sharpnack DD ; Vet Path Services, Inc., Mason 45040, Ohio. Nayak AP ; Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505; Anderson KL ; Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505; Jean Meade B ; Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505; Anderson SE ; Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505; ; Content Provider, MEDLINE Ultimate ; 초록, Triclosan is an antimicrobial chemical incorporated into many personal, medical and household products. Approximately, 75% of the U.S. population has detectable levels of triclosan in their urine, and although it is not typically considered a contact sensitizer, recent studies have begun to link triclosan exposure with augmented allergic disease. We examined the effects of dermal triclosan exposure on the skin and lymph nodes of mice and in a human skin model to identify mechanisms for augmenting allergic responses. Triclosan (0%-3%) was applied topically at 24-h intervals to the ear pinnae of OVA-sensitized BALB/c mice. Skin and draining lymph nodes were evaluated for cellular responses and cytokine expression over time. The effects of triclosan (0%-0.75%) on cytokine expression in a human skin tissue model were also examined. Exposure to triclosan increased the expression of TSLP, IL-1β, and TNF-α in the skin with concomitant decreases in IL-25, IL-33, and IL-1α. Similar changes in TSLP, IL1B, and IL33 expression occurred in human skin. Topical application of triclosan also increased draining lymph node cellularity consisting of activated CD86(+)GL-7(+) B cells, CD80(+)CD86(+) dendritic cells, GATA-3(+)OX-40(+)IL-4(+)IL-13(+) Th2 cells and IL-17 A(+) CD4 T cells. In vivo antibody blockade of TSLP reduced skin irritation, IL-1β expression, lymph node cellularity, and Th2 responses augmented by triclosan. Repeated dermal exposure to triclosan induces TSLP expression in skin tissue as a potential mechanism for augmenting allergic responses. (Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US.) ; Publication Type, Journal Article; Research Support, U.S. Gov't, P.H.S.
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Repeated dermal exposure to triclosan induces TSLP expression in skin tissue as a potential mechanism for augmenting allergic responses. Keywords: OVA; TSLP; Th2; allergy; triclosan.
and allergy and disruptions may contribute to development of allergic disease. To investigate potential connections of the skin barrier and microbiome with immune responses to triclosan...
9 Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass. Abstract Background: In cross-sectional studies triclosan and...