A bispecific antibody that facilitates physical interactions between conventional type I dendritic cells and CD8+ PD-1+ T cells enhances immune pathways required for aPD-1-mediated response and res...
Cellular immunity , also known as cell-mediated immunity , is an immune response that does not rely on the production of antibodies. Rather, cell-mediated immunity is the activation of phagocytes, antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to...
When and how T cells make effector or memory decisions is not fully resolved. Abadie, Clark, and Valanparambil et al. uncover a reversible epigenetic switch enabling memory cells to diverge early a...
The cancer-immunity cycle provides a framework to understand the events that generate anti-cancer immune responses. Mellman, Chen, Powles, and Turley consider the last 10 years of research in cance...
Sekine et al. provide a functional and phenotypic map of SARS-CoV-2-specific T cells across the full spectrum of exposure, infection, and COVID-19 severity. They observe that SARS-CoV-2 elicits bro...
Our understanding of T cell responses in COVID-19 and vaccination is incomplete. Gao et al. examine SARS-CoV-2-specific T cell responses to infection and vaccination, revealing disparate kinetics b...
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Understanding age-associated defects in T cell immunity Abstract The ability of the immune system to protect against antigenic challenges declines with increasing age, leading to increased suscepti...
humoral immunity. Importantly, defining the frequency, immune function, and specificity of the antibodies; memory B and T cell responses among COVID-19 patients; and identifying when they...
In this review, Han et al. discuss the immune and metabolic changes associated with aging, with a focus on age-related T cell subsets and the impact of aging on cancer immunity and therapy.