In chemistry, solid-phase synthesis is a method in which molecules are covalently bound on a solid support material and synthesised step-by-step in a single reaction vessel utilising selective protecting group chemistry. Benefits compared with normal synthesis in a liquid state include: Hi...
Solution-phase Synthesis and Preliminary Evaluation of 1,6,8-Trisubstituted Tetrahydro-2H-pyrazino[1,2-a]pyrimidin-4,7-dione Derivatives as a NF-kB Inhibitor Jin-Woong Kim , Su-Chul Lee , Hyeong Beom Pa 외 5명...
Solid-phase synthesis of C-terminal azapeptides. by Ngoc-Duc Doan, Jinqiang Zhang, Mariam Traoré, Winnie Kamdem, William D Lubell. Journal of peptide science : an official publication of the Europe...
We describe the first solid-phase synthesis of dihydrovirginiamycin S(1), a member of the streptogramin B family of antibiotics, which are nonribosomal-peptide natural products produced by Streptom...
AbstractAn efficient solid-phase synthesis of benzisothiazolone-1,1-dioxide-based serine protease inhibitors involving alkylation of carboxylic acids with N-(bromomethyl)benzisothiazolone-1,1-dioxi...
Solid-phase synthesis and biologic activity of human parathyroid hormone (1-84). by N A Goud, R L McKee, M K Sardana, P A DeHaven, E Huelar, M M Syed, R A Goud, S W Gibbons, J E Fisher, J J Levy. J...
Synthesis and Characterization of Microporous Polymers Based on a... 10 Synthesis and Characterization of Microporous Polymers Based on... 04 Synthesis of New Pyrazolo[5,1-c]triazine, Triazolo[5,1-c]...
AbstractThe synthesis of N-linked peptides on solid phase is accomplished using a resin bound Boc equivalent. The formation of the peptide bond is done by an activated 2, 4-dinitrophenyl ester inte...
All oligonucleotides are made by phosphoramidite solid-phase synthesis. The steps in solid phase synthesis, and the preparation of reagents.
This review article highlights the strategies to successfully perform an efficient solid-phase synthesis of complex peptides including posttranslational modifications, fluorescent labels, and repor...