Objectives: ; Identify the mechanism of action of simvastatin. ; Review the indications for using simvastatin in lipid control. ; Explain the adverse event profile of simvastatin and how it compares with other statin medications.
In 2012, the Clinical Pharmacogenetics Implementation Consortium has released guidelines regarding the use of rs4149056 genotype in guiding dosing of simvastatin and updated the guideline...
Medscape - Hypercholesterolemia-specific dosing for Zocor, FloLipid (simvastatin), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, a...
Recent Examples on the Web ; Simvastatin: The dosage of amlodipine needs to be reduced when used in combination with simvastatin, a cholesterol medication (brand name Zocor). Megan Nunn, Verywell Health, 19 Sep. 2024 ; Patients can obtain low-dose simvastatin without a prescription, but the medications are placed behind the pharmacy counter and distributed after a pharmacist’s consultation. Joshua Cohen, Forbes, 2 Mar. 2024 ; One is called simvastatin, used to manage high cholesterol. Dina Fin...
Sitagliptin/simvastatin , sold under the brand name Juvisync , is a fixed-dose combination anti-diabetic medication used to treat type 2 diabetes and hypercholesterolemia. It contains sitagliptin and simvastatin. Sitagliptin is a dipeptidyl peptidase-4 inhibitor and simvastatin is an HMG-C...
11,777,291 · Comparison of therapy with simvastatin 80 mg and 120 mg in patients with familial hypercholesterolaemia. High-dose preparations of simvastatin and atorvastatin have recently become available to treat resistant hypercholesterolaemia aggressively, but few studies have compared these two agents. This study compared the efficacy of simvastatin 80 mg and 120 mg in 22 patients with severe familial hypercholesterolaemia over a three-month period using an open label format. Simvastatin 12...
OVERVIEW ; Introduction ; Background ; Hepatotoxicity ; Mechanism of Injury ; Outcome and Management
ZOCOR (simvastatin) Tablets Initial U.S. Approval: 1991 RECENT MAJOR CHANGES Dosage and Administration Recommended Dosing (2.1) 06/2011 Restricted Dosing for 80 mg (2.2) 06/2011...
Safety Announcement · [12-15-2011] The U.S. Food and Drug Administration (FDA) is notifying the public that it has revised the dose limitation for the cholesterol-lowering drug simvastatin from 10 mg to 20 mg when it is co-administered with the cardiac drug amiodarone. In June 2011, FDA previously recommended that the dose limitation for simvastatin be decreased from 20 mg to 10 mg, and has now reconsidered that recommendation. In patients who are taking both simvastatin and amiodarone, the do...
Tell your doctor right away if you experience: Simvastatin is... Simvastatin oral tablet is available as the brand-name drug... Simvastatin oral tablet is used to: Simvastatin belongs to...