[4] However, alcoholic family roles have not withstood the standards that psychological... dependence, in 1996 there were an estimated amount of 26.8 million children of alcoholics (COAs)...
Why is addiction considered a family disease? Alcoholism or any type of addiction affects everyone in the fami
The partner and the child of an alcoholic former investment... their family for support. 'It seems to me that there is no review for someone deemed to be a low risk in this waiting period...
저자, Dostalikova-Cimburova M ; Department of Cell and Molecular Biology, Third Faculty of Medicine, Charles University Prague, Prague, Czech Republic. Balusikova K Kratka K Chmelikova J Hejda V Hnanicek J Neubauerova J Vranova J Kovar J Horak J ; Content Provider, MEDLINE Ultimate ; 초록, Patients with alcoholic liver disease (ALD) often display disturbed iron indices. Hepcidin, a key regulator of iron metabolism, has been shown to be down-regulated by alcohol in cell lines and animal models. This down-regulation led to increased duodenal iron transport and absorption in animals. In this study, we investigated gene expression of duodenal iron transport molecules and hepcidin in three groups of patients with ALD (with anaemia, with iron overload and without iron overload) and controls. Expression of DMT1, FPN1, DCYTB, HEPH, HFE and TFR1 was measured in duodenal biopsies by using real-time PCR and Western blot. Serum hepcidin levels were measured by using ELISA. Serum hepcidin was decreased in patients with ALD. At the mRNA level, expressions of DMT1, FPN1 and TFR1 genes were significantly increased in ALD. This pattern was even more pronounced in the subgroups of patients without iron overload and with anaemia. Protein expression of FPN1 paralleled the increase at the mRNA level in the group of patients with ALD. Serum ferritin was negatively correlated with DMT1 mRNA. The down-regulation of hepcidin expression leading to up-regulation of iron transporters expression in the duodenum seems to explain iron metabolism disturbances in ALD. Alcohol consumption very probably causes suppression of hepcidin expression in patients with ALD. (© 2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.) ; Publication Type, Journal Article; Research Support, Non-U.S. Gov't
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The Interpersonal and Emotional Consequences of Being an Adult Child of an Alcoholic (2009)... Personality, coping, and family resources in stress resistance: a longitudinal analysis. (1986) C J...
The purpose of this study was to test a conceptual model predicting children's externalizing behavior problems in kindergarten in a sample of children with alcoholic (n = 130) and nonalcoholic (n =...
Various influences in the family environment contribute to children of alcoholics' (COAs') risk of developing alcoholism and other mental health problems. These risk factors include alcohol-specifi...
Adolescents' non-alcoholic drinks preferences are strongly influenced by their own individual circumstances and lifestyle choices, but not by their families and home environment, according to a new...
ease, in particular non-alcoholic fatty liver disease (NAFLD). With prevalence estimated up... is an open access article under the terms of the Creative Commons Attribution-NonCommercial...