Dabigatran Clinical data Trade names Pradaxa, Pradax, Prazaxa, others Other names BIBR-953... Elimination half-life 12–17 hours [6] Identifiers CAS Number 211914-51-1 as etexilate: 211915...
use PRADAXA Capsules safely and effectively. See full prescribing information for PRADAXA Capsules. PRADAXA® (dabigatran etexilate) capsules, for oral use Initial U.S. Approval: 2010...
WARNING: (A) PREMATURE DISCONTINUATION OF PRADAXA INCREASES THE RISK OF THROMBOTIC EVENTS, (B) SPINAL/EPIDURAL HEMATOMA (A) PREMATURE DISCONTINUATION OF PRADAXA INCREASES THE RISK OF...
WARNING: (A) PREMATURE DISCONTINUATION OF PRADAXA INCREASES THE RISK OF THROMBOTIC EVENTS, (B) SPINAL/EPIDURAL HEMATOMA (A) PREMATURE DISCONTINUATION OF PRADAXA INCREASES THE RISK OF...
Dabigatran etexilate INN: Dabigatran etexilate Clinical data Trade names Pradaxa, Pradax... Elimination half-life 12–17 hours [2] Identifiers IUPAC name Ethyl N -[(2-{[(4-{ N...
What is Pradaxa? ; Pradaxa contains the active drug dabigatran, which belongs to the drug class called direct thrombin inhibitors. (A class of drugs is a group of medications that work in a similar way.) Pradaxa is a type of anticoagulant. Pradaxa comes as a capsule that you swallow. You’ll usually take the drug once or twice a day. Clinical studies looked at how well Pradaxa works to help prevent blood clots in people with nonvalvular A-fib. Blood clots can be very serious, and PEs or DVTs can sometimes result in death, so it’s very import ...
[1] The most common life-threatening concern with DVT is the potential for a clot to embolize... [31][32] It is life-threatening, limb-threatening, and carries a risk of venous gangrene....
Boehringer Ingelheim Pharmaceuticals, Inc. recently announced phase I data that showed administration of investigational idarucizumab in healthy volunteers who were middle-aged (45 to 64 years) or elderly (65 to 80 years), or volunteers with mild or moderate kidney impairment, resulted in immediate, complete and sustained reversal of the anticoagulation effects of dabigatran (PRADAXA) (ClinicalTrials.gov Identifier: NCT01955720). Further, anticoagulation was restored when volunteers were re-dosed with dabigatran 24 hours after idarucizumab was ...
of PRADAXA is 300 mg taken orally as 150 mg hard capsules twice daily, unless otherwise stated. Therapy should be continued life-long. In case of intolerability, patients should be...
Pradaxa Generic Name & Formulations ; Legal Class · Rx ; General Description · Dabigatran etexilate mesylate 75mg, 110mg, 150mg; caps. Pharmacological Class · Direct thrombin inhibitor. Generic Availability · NO ; Mechanism of Action · Dabigatran and its acyl glucuronides are competitive, direct thrombin inhibitors. Since thrombin (serine protease) enables the conversion of fibrinogen into fibrin during the coagulation cascade, its inhibition prevents the development of a thrombus. Indications · To reduce risk of stroke and systemic embol ...