1 Dabigatran etexilate(Pradaxa® cap) 목차 ♦ Special issue. 4 ♦ 의약품 안전성 정보. 8... 5) half life elimination : 12~17hr; elderly 14~17hr, mild~moderate renal impairment 15~18hr, severe renal impairment...
"What really compounds the matter is the lack of a specific antidote to reverse life-threatening bleeding" from Pradaxa, said Kaul, who served on independent panels that advised the FDA on...
ABBREVIATIONS: aPTT : activated partial thromboplastin time, ECT : Ecarin clotting time, INR : international normalized ratio, pGP : P-glycoprotein, TT : thrombin clotting time
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Over half a million people have left blood thinners behind for life with the WATCHMANTM Implant. Stroke risk reduction... Newer blood thinners include Eliquis® (apixaban), Pradaxa...
Anticoagulant, Half-life, Removed by HD, Strategies to reverse or minimize anticoagulant effects ; Apixaban [1] (Eliquis®), 8-15 hrs (longer in renal impairment), No, If ingested within 2 hours, administer activated charcoal 4-factor PCC (Kcentra™)^ 25units/kg—max 2500 units for treatment of documented intracranial hemorrhage 50 units/kg—max 5000 units for all other life-threatening bleeds ; Edoxaban [2] (Savaysa®), 10-14 hrs (longer in renal impairment), ~ 25%, As above ; Rivaroxaban [3] (Xarelto®), 9-13 hrs (longer in renal impairment), No, As above ; Fondaparinux (Arixtra®), 17-21 hrs (significantly longer in renal impairment), No, 4-factor PCC (Kcentra™)^ 50 units/kg—max 5000 units
Dabigatran , sold under the brand name Pradaxa among others, is an anticoagulant used to... Pharmacokinetics Dabigatran has a half-life of approximately 12–17 h and exerts a maximum...
Treatment with PRADAXA 150 mg led to a 59 percent reduction in intracranial hemorrhage, compared to warfarin (38 vs. 90), and showed numerically lower rates of fatal and life-threatening...
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WARNING: (A) PREMATURE DISCONTINUATION OF PRADAXA INCREASES THE RISK OF THROMBOTIC EVENTS, (B) SPINAL/EPIDURAL HEMATOMA (A) PREMATURE DISCONTINUATION OF PRADAXA INCREASES THE RISK OF...