of phosphodiesterase 4 (PDE4) on cyclic adenosine monophosphate (cAMP). It is a member of the larger family of PDE inhibitors. The PDE4 family of enzymes are the most prevalent PDE in...
[3][4] The potential for selective phosphodiesterase inhibitors as therapeutic agents was predicted as early as 1977 by Weiss and Hait. [5] This prediction meanwhile has proved to be true...
v t e Phosphodiesterase inhibitors PDE1 MMPX SCH-51866 Vinpocetine PDE2 BAY 60-7550 Carbazeran EHNA Oxindole PDP PDE3 Adibendan Amrinone (inamrinone) Anagrelide Benafentrine Bucladesine...
Summary Inhibitors of phosphodiesterase type 4 (PDE4) act by increasing intracellular concentrations of cyclic AMP, which has a broad range of anti-inflammatory effects on various key effector cell...
PDE4 inhibitors are a new type of treatment for plaque psoriasis that prevents inflammation. Here's what you need to know.
The IUPHAR/BPS Guide to Pharmacology. phosphodiesterase 4A - Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs). Detailed annotation on the structure, function, physiology, pharmacology and clinica...
Phosphodiesterase-4 inhibitors (PDE4Is) are potent anti-inf lammatory agents and roflumilast has been used to prevent acute exacerbation of chronic obstructive pulmonary disease (COPD). Roflumilast...
Discovery of new orally active phosphodiesterase (PDE4) inhibitors. by Hiroshi Ochiai, Akiharu Ishida, Tazumi Ohtani, Kensuke Kusumi, Katuya Kishikawa, Susumu Yamamoto, Hiroshi Takeda, Takaaki Obat...
The IUPHAR/BPS Guide to Pharmacology. phosphodiesterase 4C - Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs). Detailed annotation on the structure, function, physiology, pharmacology and clinica...
Phosphodiesterase inhibitors constitute a widely used class of drugs that may see growing use for inflammatory dermatologic diseases.