Phorbol esters are a class of chemical compounds found in a variety of plants, particularly in the families Euphorbiaceae and Thymelaeaceae. Chemically, they are ester derivatives of the tetracyclic diterpenoid phorbol. Biological activity Protein kinase C (PKC) is a phorbol ester receptor...
phorbol ester [화합물] 구조정보 화합물 이름 phorbol ester CAS 번호 16561-29-8 화학식 C 36 H 56 O 8 분자량 616.8336 CNMR 65.70(C2), 76.10(C3), 36.10(C4), 39.40(C5), 132.70(C6), 151.42(C7), 62.54(C8), H...
Phorbol is a natural, plant-derived organic compound. It is a member of the tigliane family of diterpenes. Phorbol was first isolated in 1934 as the hydrolysis product of croton oil, which is derived from the seeds of the purging croton, Croton tiglium . The structure of phorbol was determ...
PMA는 가장 흔하고 강력한 phorbol ester이며, nM 농도에서 활성을 가지며, dose-dependent 하게 NF-κB를 활성화시킵니다. PMA는 세포와 조직에서 광범위한 영향을...
The effect of phorbol esters on the extent of phosphorylation of receptors for insulin and somatomedin C (insulin-like growth factor I) was studied in intact IM-9 cells that were labeled by incubat...
Tumour-promoting phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate (TPA), which activate Ca2+ -activated, phospholipid-dependent protein kinase (protein kinase C)10 , can also...
Abstract. Interaction of tumor promoting phorbol esters with specific high affinity receptors is probably essential for many of the biological responses
and phorbol-12,13- dibutyrate) all known to cause metamorphosis in thoracican barnacles. Only one agent, phorbol-12,13-dibutyrate, had an effect and induced cypris larvae to complete...
화합물 이름 phorbol ester CAS 번호 16561-29-8 화학식 C 36 H 56 O 8 분자량 616.8336 CNMR 65.70(C2), 76.10(C3), 36.10(C4), 39.40(C5), 132.70(C6), 151.42(C7), 62.54(C8), H(C10), 78.20(C11)...
567-571, January 1980 MedicalSciences Specific binding ofphorbol ester tumor promoters... Pardee, September 6,1979 ABSTRACT [20-3H]Phorbol 12,13-dibutyrate bound to particulate preparations...