The discovery of phosphodiesterase 5 inhibitors (PDE5 inhibitors) for causing the erection of the penis was accidental, noticed as a side effect while being administered to investigate their abilit...
PDE-3, PDE-4, PDE-5, Non-selective ; Amrinone/Inamrinone, Apremilast, Avanafil, Caffeine* ; Anagrelide, Crisaborole, Sildenafil, Pentoxifylline ; Cilostazol, Roflumilast, Tadalafil, Theophylline ; Dipyridamole, , Vardenafil,
A PDE3 inhibitor is a drug which inhibits the action of the phosphodiesterase enzyme PDE3. They are used for the therapy of acute heart failure and cardiogenic shock. Medical uses Cardiac Amrinone, milrinone and enoximone are used clinically for short-term treatment of cardiac failure in t...
A phosphodiesterase-4 inhibitor , commonly referred to as a PDE4 inhibitor , is a drug used to block the degradative action of phosphodiesterase 4 (PDE4) on cyclic adenosine monophosphate (cAMP). It is a member of the larger family of PDE inhibitors. The PDE4 family of enzymes are the most...
Because PDE5 is also present in the smooth muscle of the walls of the arterioles within the lungs, two PDE5 inhibitors, sildenafil and tadalafil, are FDA-approved for the treatment of...
PDE-4 inhibitors are a new type of topical treatment for atopic dermatitis. Learn how these medications work and what to expect if you use them.
PDE5 inhibitors are a group of medications typically used to treat physiological causes of erectile dysfunction (ED). Learn about the most common types of PDE5 inhibitors, how they work and how muc...
Abbreviations ; ED : erectile dysfunction, LUTS : lower urinary tract symptoms, NANC : non‐adrenergic non‐cholinergic, PAH : pulmonary arterial hypertension, PKG : cGMP‐dependent protein kinase
Discover how phosphodiesterase-4 (PDE-4) inhibitors manage inflammation in people with mild to severe plaque psoriasis.