Management of atrial fibrillation Specialty Cardiology (cardiac electrophysiology) [edit on Wikidata ] The management of atrial fibrillation (AF) is focused on preventing temporary...
Atrial septal defect Illustration of an atrial septal defect. Specialty Cardiac surgery... [citation needed] The mechanism by which a PFO may play a role in stroke is called paradoxical...
Abstract Importance: White persons have a higher risk of atrial fibrillation (AF) compared... this paradoxical differential racial risk for AF and to use admixture mapping to search genome...
Paradoxical embolism Other names Crossed embolism Specialty Cardiology An embolus, is... [10] An EKG may be started to evaluate for abnormal heart rhythms, especially atrial fibrillation...
심방세동(Atrial Fibrillation, 이하 AF)은 가장 흔한 지속적인 부정맥으로 전 세계적으로 많은 환자들이... 이외에도 패러독스적 상황(paradoxical situations)이 발생할 수 있습니다. 전기적 신호는 때로는 너무 빨리...
for Atrial Fibrillation Leste , Y. Leung , Ma 외 4명 대한뇌졸중학회지 2017 Antithrombotic Management of Patients with Nonvalvular Atrial Fibrillation and Ischemic Stroke or Transient Ischemic Attack...
Abstract Background and purpose: The Risk of Paradoxical Embolism (RoPE) score stratifies... covert atrial fibrillation. We aimed to validate the RoPE score in a large ESUS population and...
with atrial fibrillation (AF). We aimed to provide insight into the paradoxical association of LDL cholesterol with AF by evaluating the relationship of various lipoprotein measures and...
저자, Ponce-Balbuena D ; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.; Center for Arrhythmia Research, University of Michigan, MI 48109, USA. Tyrrell DJ ; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA. Cruz-Cortés C ; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.; Center for Arrhythmia Research, University of Michigan, MI 48109, USA. Guerrero-Serna G ; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.; Center for Arrhythmia Research, University of Michigan, MI 48109, USA. Da Rocha AM ; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.; Center for Arrhythmia Research, University of Michigan, MI 48109, USA. Herron TJ ; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.; Center for Arrhythmia Research, University of Michigan, MI 48109, USA. Song J ; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. Raza DS ; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.; Center for Arrhythmia Research, University of Michigan, MI 48109, USA. Anumonwo J ; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.; Center for Arrhythmia Research, University of Michigan, MI 48109, USA. Goldstein DR ; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.; Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Microbiology and Immunology, University of Michigan, MI 48109, USA. Espinoza-Fonseca LM ; Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.; Center for Arrhythmia Research, University of Michigan, MI 48109, USA. ; Content Provider, MEDLINE Ultimate ; 초록, Obesity is a major risk factor for atrial fibrillation (AF) the most common serious cardiac arrhythmia, but the molecular mechanisms underlying diet-induced AF remain unclear. In this study, we subjected mice to a chronic high-fat diet and acute sympathetic activation ('two-hit' model) to study the mechanisms by which diet-induced obesity promotes AF. Surface electrocardiography revealed that diet-induced obesity and sympathetic activation synergize during intracardiac tachypacing to induce AF. At the cellular level, diet-induced obesity and acute adrenergic stimulation facilitate the formation of delayed afterdepolarizations in atrial myocytes, implicating altered Ca 2+ dynamics as the underlying cause of AF. We found that diet-induced obesity does not alter the expression of major Ca 2+ -handling proteins in atria, including the sarcoplasmic reticulum Ca 2+ -ATPase (SERCA), a major component of beat-to-beat Ca 2+ cycling in the heart. Paradoxically, obesity reduces phospholamban phosphorylation, suggesting decreased SERCA activity, yet atrial myocytes from obese mice showed a significantly increased Ca 2+ transient amplitude and SERCA-mediated Ca 2+ uptake. Adrenergic stimulation further increases the Ca 2+ transient amplitude but does not affect Ca 2+ reuptake in atrial myocytes from obese mice. Transcriptomics analysis showed that a high-fat diet prompts upregulation of neuronatin, a protein that has been implicated in obesity and is known to stimulate SERCA activity. We propose a mechanism in which obesity primes SERCA for paradoxical activation, and adrenergic stimulation facilitates AF conversion through a Ca 2+ -induced Ca 2+ release gain in atrial myocytes. Overall, this study links obesity, altered Ca 2+ signaling, and AF, and targeting this mechanism may prove effective for treating obesity-induced AF. Competing Interests: Competing Interest Statement: D.P.-B., D.J.T., C.C.-C., G.G.S., A.M.D.R., J.S., D.S.R., J.A., D.R.G., and L.M.E.-F. declare no competing interests. T.J.H is co-founder of Cartox, Inc., and scientific advisor to StemBioSys, Inc. ; Publication Type, Journal Article; Preprint
Four hours later after the procedure, the patient developed palpitations at rest and his ECG monitor recorded an intermittently fast and irregularly ventricular paced rhythm with rates up to the programmed upper rate limit of 120 bpm. Pacemaker interrogation documented atrial fibrillation (AF) with amplitudes of 0.5–3.0 mV. Atrial lead impedance was 507 Ω and about the same as those at the implantation. After a while of observation, the sensitivity was re-programming to 0.2 mV from 0.5 mV sin ...