Rare germline variants in known melanoma susceptibility genes in familial melano

Known high-risk cutaneous malignant melanoma (CMM) genes account for melanoma risk in <40% of melanoma-prone families, suggesting the existence of additional high-risk genes or perhaps a polygenic...

What Causes Melanoma? | Causes of Melanoma Skin Cancer | American Cancer Society

But our genes affect more than just how we look. Some genes control when our cells grow and divide into new cells, repair mistakes in DNA, or cause cells to die when they’re supposed to. If these genes aren’t working properly, it can lead to cells growing out of control. For example: ...

Epigenetic Silencing of Novel Tumor Suppressors in Malignant Melanoma | Cancer Research

We show DNA methylation and silencing of 17 genes in melanoma cell lines and in uncultured melanoma tumor samples. DNA methylation has not been previously shown in eight of these genes in...

Expression of Autoimmunity-Related Genes in Melanoma

We therefore investigated the expression of autoimmunity related genes in melanoma patients as compared to healthy controls. To this aim the expression of 98 genes was investigated in 1948...

Assessing the genetic risk of nodular melanoma using a candidate gene approach |

This study performed a rare variant allele analysis of whole exome sequenced nodular and non-nodular melanoma patients for a set of 500 candidate genes already

MCAM melanoma cell adhesion molecule [Homo sapiens (human)] - Gene - NCBI - 미국 국립생물정보센터

Biomarker of chronic obstructive pulmonary disease and uveal melanoma. [provided by Alliance of Genome Resources, Apr 2022] Broad expression in fat (RPKM 237.1), placenta (RPKM 102.0) and...

AIM2 absent in melanoma 2 [Homo sapiens (human)] - Gene - NCBI - 미국 국립생물정보센터

AIM2provided by HGNCabsent in melanoma 2 provided by HGNC HGNC:HGNC:357 Ensembl:ENSG00000163568 MIM:604578; AllianceGenome:HGNC:357 protein coding REVIEWED Homo sapiens Eukaryota; Metazoa;...

A newly discovered tumor suppressor gene affects melanoma survival

Of the hundreds of genes that can be mutated in a single case of melanoma, only a handful may be true "drivers" of cancer. In research that appeared today in Nature Genetics, a Weizmann Institute of Science team has now revealed one of the drivers of a particularly deadly subset of melanomas - one that is still seeing a rise in new cases. This gene is a newly identified member of a group of genes called tumor suppressor genes. It is mutated in some 5.4% of melanomas. Furthermore, its expression ...

Melanoma gene expression and clinical course

We studied the expression of certain melanoma genes in tissue biopsies from 202 patients using reverse transcriptase-polymerase chain reaction (RT-PCR). The evaluated genes were Melan-A...

Gene Expression Profiling in Uveal Melanoma Reveals Two Molecular Classes and Predicts Metastatic Death |....

Genes that discriminate class 1 (low-grade) from class 2 (high-grade) include highly... These studies offer new insights into melanoma pathogenesis, and they provide a practical foundation...