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IJMS | Free Full-Text | The Role of Tumor Microenvironment in Pancreatic Cancer

Pancreatic cancer comprises different subtypes, where most cases include ductal adenocarcinoma (PDAC). It is one of the deadliest tumor types, with a poor prognosis. In the majority of patients, th...

Unveiling the Promise: Navigating Clinical Trials 1978–2024 for PDAC

Despite many decades of research, pancreatic ductal adenocarcinoma (PDAC) remains one of the most difficult cancers to diagnose and treat effectively. Although there have been improvements in the 5...

Cancers | Free Full-Text | Is Sphingosine-1-Phosphate a Regulator of Tumor Vascu

as cancer therapy, effectively achieving this strategy in the clinic remains complex. In the... This approach is proposed following a clinical observation in pancreatic adenocarcinoma...

Frontiers | Orphan Medicinal Products for the Treatment of Pancreatic Cancer: Le

Pancreatic cancer has a dismal prognosis and only a few treatment options are available. In the European Union, pancreatic cancer classifies as a rare dis...

Pharmaceuticals | Free Full-Text | Drug Repurposing Opportunities in Pancreatic

pancreatic cancer; therapeutic strategies 1. Drug Repurposing: An Attractive and Challenging Approach Drug repurposing has been emerging as an interesting alternative to the conventional...

IJMS | Free Full-Text | Wnt/β-Catenin Signaling: The Culprit in Pancreatic Carci

Pancreatic ductal adenocarcinoma (PDAC) is responsible for 7.3% of all cancer deaths. Even though there is a steady increase in patient survival for most cancers over the decades, the patient survi...

IJMS | Free Full-Text | Clinical and Preclinical Targeting of Oncogenic Pathways

Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related death worldwide. It is commonly diagnosed in advanced stages and therapeutic interventions are typically const...

Cancers | Free Full-Text | Predictive Values of Blood-Based RNA Signatures for t

Pancreatic ductal adenocarcinoma (PDAC) is expected to be the second cause of cancer death by 2022. For nearly 80% of patients, diagnosis occurs at an advanced, nonsurgical stage, making such patie...

KR20230047210A - Methods of treating pancreatic cancer - Google Patents

The present disclosure provides a method for treating pancreatic cancer and limiting the over-expression of oncogenes, activating tumor suppressor genes or regulating signaling proteins in patients...

Gemcitabine mono-therapy versus gemcitabine plus targeted therapy in advanced pa

The present meta-analysis does not show significant improvements in survival for targeted drugs in advanced pancreatic cancer. The possible reason of these results could be linked to the biology of...

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