What’s new in the treatment of prostate cancer with immunotherapy? Urologic oncologist Bilal Siddiqui, M.D., weighs in.
Cancer vaccine ; Sipuleucel-T (Provenge) is a cancer vaccine. Unlike traditional vaccines, which boost the body’s immune system to help prevent infections, this vaccine boosts the immune system to help it attack prostate cancer cells. The vaccine is used to treat advanced prostate cancer that's no longer responding to hormone therapy but that is causing few or no symptoms. This vaccine is made specifically for each man. To make it, white blood cells (cells of the immune system) are removed fro...
With a cancer vaccine and checkpoint inhibitor approved, immunotherapy for prostate cancer offers new hope to patients with advanced prostate cancer.
clinical development of immunotherapy for prostate cancer is discussed. Keywords: cancer vaccine; chimeric antigen receptor T cells; immunotherapy; prostate cancer; tumor microenvironment.
Immunotherapy has changed the treatment landscape for some cancers but has not produced the same benefits in prostate cancer.
Prostate cancer, notoriously resistant to immunotherapy due to its immunologically cool nature, triggers two pathways to chill an immune attack after one immunotherapy drug fires up the immune syst...
Several unanswered questions remain, including the following: is there—or will there ever be—a role for immunotherapy in prostate cancer? In this review, we aim at underlining the...
The exclusive expression of well-defined antigens renders prostate cancer an attractive target for immunotherapy. Di Lorenzoet al. review clinical results of immunotherapy trials in patients with p...
in prostate cancer treatment have not yet been achieved. The disappointing previous results... criteria for patients with high mutation burdens, especially those with mismatch repair...
The immune system has the remarkable ability to kills cells that can cause harm, such as infected cells or cancer cells. However, in most patients with progressing cancer, anti-cancer immune responses either never developed or have been turned off by the cancer. One way to fight cancer is to hack the immune system, retraining immune cells to respond to the malfunctioning cancer cells. Sipuleucel-T (Provenge®) is a cell-based prostate cancer vaccine that has been approved by the FDA for men wit...