잠재항원결정부 - 생명과학대사전

항원분자상의 항원결정부에서 보통상태에서는 면역계에 노출되지 않은 것을 말한다. T세포가 인식하는 항원결정부의 경우, 구체적으로는 그 배열만으로는 MHC분자에 결합할 수 있음에도 불구하고 항원제시세포...

Cryptic MHC-E epitope from influenza elicits a potent cytolytic T cell response | Nature Immunology

Similarly uncertain is the importance of ‘cryptic’ viral epitopes, defined as those... We identified a nine amino acid epitope, termed M-SL9, that drives a co-immunodominant, cytolytic...

Cryptotope

[2] A cryptotope can also be referred to as a cryptic epitope. Cryptotopes are becoming important for HIV vaccine research as a number of studies have shown that cryptic epitopes can be...

A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV | Science

Targeting the SARS-CoV-2 spike · The surface of severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) is decorated with trimeric spikes that bind to host cell receptors. These spikes also elicit an antibody response, so understanding antibody recognition may aid in vaccine design. Yuan et al. determined the structure of CR3022, a neutralizing antibody obtained from a convalescent SARS-CoV–infected patient, in complex with the receptor-binding domain of the SARS-CoV-2 spike. The anti...

Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV

conserved cryptic epitope on the Nipah virus G protein Yulu Wang Yifang Sun Yanling Wu Nature Communications (2024) Potent and broadly neutralizing antibodies against sarbecoviruses induced...

Fully human single-domain antibody targeting a highly conserved cryptic epitope

Here, we identify a fully human single-domain antibody that targets a highly conserved cryptic epitope situated at the dimeric interface of the Nipah virus G protein (receptor binding...

Fibrotic remodeling of the extracellular matrix through a novel (engineered, dua - Merck

Fibrotic remodeling of the extracellular matrix through a novel (engineered, dual-function) antibody reactive to a cryptic epitope on the N-terminal 30 kDa fragment of fibronectin. by Maryada Sharm...

Cryptic Epitope - De Gruyter

Requires Authentication Published by De Gruyter2016 (Print 2012) Cryptic Epitope From: IUPAC Glossary of Terms Used in Immunotoxicology Douglas M. Templeton , Michael Schwenk , Reinhild...

Identification of a new HLA‐A*0201‐restricted cryptic epitope from CYP1B1 - Maec

These findings indicate that CYP246 is a candidate cryptic epitope for immune interventions in which tumor CYP1B1 is targeted. © 2005 Wiley-Liss, Inc.

Unmasking cryptic epitopes after loss of immunodominant tumor antigen expression

In this study we document the surfacing of systemic immune reactivity toward a cryptic epitope from the MAGE-12 gene (MAGE-12:170–178), after temporary regression of a single melanoma...