System biology approaches to identify hub genes linked with ECM organization and - Cell Press

matrix organization (ECM) organization, collagen fibril organization, integrin signaling pathway, inflammation mediated by chemokines and cytokines signaling pathway, and GABA-B receptor II...

Integrative spatial analysis reveals a multi-layered organization of glioblastom

029 Highlights •Human glioblastoma consists of disorganized and structured regions •Organization of cell states extends beyond the structure observed by histopathology •Organization...

Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeti

cristae organization Dingfeng Li Xinyi Gao Xiaolin Ma Yong Shen Juan Zhang Qiang Liu 7 Show... to Cell Metabolism Already a print subscriber? Claim online access Already an online...

Special issue: 3D chromatin organization: Cell Reports

A Cell Reports special issue focused on different aspects of 3D chromatin organization.

CELL STRUCTURE AND FUNCTION 1. Body Organization The fundamental units that make up all living things are....

Organization Cells Tissues Organs Organ systems Organism 3

Automated Design of Pluripotent Stem Cell Self-Organization: Cell Systems

Highlights •Extended cellular Potts model captures pluripotent stem cell organization dynamics •Machine learning optimization yields conditions for multicellular patterns •In silico...

Multi-omic profiling reveals the ataxia protein sacsin is required for integrin

Highlights •Sacsin regulates cytoskeletal organization, microtubule dynamics, and protein... Purkinje cell loss, which is thought to have both neurodegenerative and neurodevelopmental...

Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization: - Cell Press

High-throughput imaging of several hundred chromatin interactions in individual cells reveals extensive heterogenity in spatial genome organization at the single-cell level.

Cell states beyond transcriptomics: Integrating structural organization and gene

This study establishes a framework for multidimensional analysis in single cells to study the relationship between gene expression and cell organization. The quantitative and automated image analys...

Deep learning of cell spatial organizations identifies clinically relevant insig

For instance, in the context of lung cancer subtypes, we aim to see if Ceograph can capture the nuanced differences in cell organization between lung squamous cell carcinoma (SCC) and lung...