The Food and Drug Administration (FDA) is requiring a boxed warning on all existing CAR-T cancer treatments following a review of reports that the therapies themselves can increase the risk for som...
A CAR T-cell therapy targeting the B7-H3 protein may have potential as a treatment for several childhood cancers, results from a study in mice suggest.
How Cellular Immunotherapies Are Changing the Outlook for Cancer Patients ; Today, cell therapies are constantly evolving and improving and providing new options to cancer patients. Cell therapies are currently being evaluated, both alone and in combination with other treatments, in a variety of cancer types in clinical trials. Cancer patients have naturally occurring T cells that are often capable of targeting their cancer cells. These T cells are some of the most powerful immune cells in our body, and come in several types. The “killer” T ...
Transformative research at EPFL introduces CAR-T cells that flourish in tumor environments, paving the way for unparalleled advancements in cancer immunotherapy.
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Overview ; To understand how CAR T-cell therapy works, it may help to know more about T cells, which are white blood cells in your immune system. Your immune system monitors your body for intruders, including cancer, by tracking proteins called antigens on the surface of intruder cells. Your T cells have their own surface proteins called receptors. These receptors can recognize cells that have abnormal antigens. T cells act as a surveillance system for abnormal cells, becoming active when a receptor recognizes an abnormal cell. The activated T ...
About This Website ; Dictionary of Cancer Terms ; Vulnerability Disclosure
A new CAR T-cell therapy for B-cell cancers promises to reduce the antigen escape currently found in therapies that only target CD19.
CAR (Chimeric Antigen Receptor) -T cell therapy is a new form of immunotherapy. It uses altered T cells to target cancer cells to target cancer cells.
Related Research Article ; By Nicola Trendel, Philipp Kruger, Stephanie Gaglione, et al. Science Signaling · 19 Jan 2021