Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines | Oncogene

MM cells that carried wild-type BRAF and NRAS showed constitutive overexpression of B-Raf protein and phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), even after serum...

Cancers | Free Full-Text | The Driverless Triple-Wild-Type (BRAF, RAS, KIT) Cuta

The genetic makeup of the triple-wild-type melanoma (BRAF, NRAS and NF1) has been known for some time, but those studies grouped together rare histopathological versions with common ones, as well a...

BRAF wild‐type malignant melanoma developing on a thermal burn - Grimaux - 2017 - Australasian Journal o....

BRAF wild-type malignant melanoma developing on a thermal burn

NAVER 학술정보 > BRAF/NRAS wild-type melanomas have a high mutation load correlating with histologic and ....

저자 : Victoria J Mar, Stephen Q Wong, Jason Li, Richard A Scolyer, Catriona McLean, Anthony T Papenfuss, Richard W Tothill, Hojabr Kakavand, Graham J Mann, John F Thompson, Andreas Behren, Jonathan S Cebon, Rory Wolfe, John W Kelly, Alexander Dobrovic, Grant A McArthur, 학술지정보 : CLINICAL CANCER RESEARCH · 4589p ~ 4598p · ISSN 1078-0432 · E-ISSN 1557-3265, 발행정보 : Medline · 2013년, 피인용횟수 : 107, 자료제공처 : MEDLINE®/PubMed® · Crossref, DOI : 10.1158/1078-0432.CCR-13-0398, 주제분야 ...

NAVER 학술정보 > Data from BRAF/NRAS Wild-Type Melanomas Have a High Mutation Load Correlating with Histo....

BRAF/NRAS wild-type (WT) tumors had a higher BRAF/NRAS–mutant (27 vs. 5.6 Mb; P 0.0001). Tandem CC>TT/GG>AA comprised 70% all dinucleotide substitutions more common arising SSD 0.0008) WT...

아스피린 복용 BRAF 변이 상태에 따른 아스피린 복용과 대장암 위험 - 암연구동향

중요성 아스피린 사용은 대장암종의 위험을 낮춘다. 상승된 prostaglandin-endoperoxide synthase 2(PTGS2, cyclooxygenase 2)가 RAF kinase 역할에 영향을 미친다는 것이 실험을 통하여 확인되었다. 이는 BRAF-mutant colonic cells이 BRAF-wild type에 비해 아스피린의 항암효과에 덜 민감할 것이라는 것을 시사한다.

Colorectal Cancer With Mutation in BRAF, KRAS, and Wild-Type With Respect to Both Oncogenes Showing Diffe....

Abstract ; Purpose : BRAF mutations are common in sporadic colorectal cancers (CRCs) with a DNA mismatch repair (MMR) deficiency that results from promoter methylation of hMLH1, whereas KRAS mutations are common in MMR proficient CRCs associated with promoter methylation of MGMT. The aim of this study was to further investigate the link between genetic alterations in the RAS/RAF/ERK pathway and an underlying epigenetic disorder. Patients and Methods : Activating mutations of BRAF and KRAS were identified and correlated with promoter methylation ...

Wild-type BRAF is required for response to panitumumab or cetuximab in metastati - 상세정보 | 인제대학교 ....

Journal of Clinical Oncology; 12/10/2008, Vol. 26 Issue 35, p5705-5712, 8p ; 자료유형 : journal article, Content Provider : Supplemental Index, Publication Year : 2008, ISSN : 0732183X, DOI : 10.1200/JCO.2008.18.0786, Accession Number : 105598259

Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma - Article 상세보기-Access....

MM cells that carried wild-type BRAF and NRAS showed constitutive overexpression of B-Raf protein and phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2), even after serum...

RCSB PDB - 3Q4C: Crystal Structure of Wild Type BRAF kinase domain in complex with organometallic inhibit....

Crystal Structure of Wild Type BRAF kinase domain in complex with organometallic inhibitor CNS292