다발성 근염, 피부근염에 특이적인 자기항체로, 항세포질항체의 하나. 히스티딘을 tRNA에 결합시키는 반응을 촉매하는 히스티딜 tRNA합성효소가 인식하는 항원이다. 히스틸딜 tRNA합성효소는 미오신과 아미노산...
Main antinuclear antibody patterns on immunofluorescence [1] Homogeneous immunofluorescence... 5 Anti-Jo-1 2.2 Anti-dsDNA 2.3 Anti-histone antibodies 2.4 Anti-gp210 and anti-p62 2.5 Anti...
Contents 1 Anti-AMPAr 2 Anti-NMDAr 3 Anti-mGluR 4 References Anti-AMPAr[edit] The first anti-glutamate receptor antibody was shown by McNamara JO and colleagues to be directed against the...
● 개요 Anti-Jo-1 항체는 항합성효소 항체(antisynthetase antibody)로 특발성 염증성 근육병증 환자에게서 가장 흔한 근염 특이 자가항체이다. 단백질 합성과정에서 히스티딘을 tRNA에...
[24] Farr assay [edit] The Farr assay is used to quantify the amount of anti-dsDNA antibodies in serum. Ammonium sulphate is used to precipitate antigen-antibody comp
Approximately 20–30% of patients with idiopathic inflammatory myopathies express anti-histidyl-tRNA synthetase (anti-Jo-1) antibodies, which are often associated with extra-muscular symptoms. Mesca...
Myopathological changes in the anti-Jo-1 antibody syndrome include perimysial connective tissue fragmentation and inflammation, with muscle fibre pathology in neighbouring perifascicular regions. M...
Anti-Jo-1 antibodies are rare autoantibodies, which bind and inhibit the activity of histidyl-tRNA-synthetase. They are predominantly found in a genetically and clinically distinct subset of myosit...
In this large cohort of anti-Jo-1 antibody-positive individuals, the incidence of ILD approached 90%. Multiplex ELISA demonstrated disease-specific associations between anti-Jo-1 antibody-positive...
Abstract Of 180 patients with polymyositis/dermatomyositis (PM/DM) seen at the University of Pittsburgh and affiliated hospitals since 1975, 21 of 100 tested positive for the anti-Jo-1 antibody. Si...