Carolyn Wester, MD, MPH ; Debika Bhattacharya, MD, MSc ; Brian Pearlman, MD, FAASLD, FACP, AAHIVS ; Jake T Liang, MD
Practice Guidance · Hepatitis C Guidance 2023 Update: American Association for the Study of Liver Diseases– Infectious Diseases Society of America Recommendations for Testing, Managing, and Treating Hepatitis C Virus Infection · The Infectious Diseases Society of America and the American Association for the Study of Liver Diseases have collaboratively developed evidence-based guidance regarding the diagnosis, management, and treatment of hepatitis C virus (HCV) infection since 2013. A pane...
CDC recommends universal hepatitis C screening for all adults 18 and older and all pregnant people during each pregnancy. ; CDC recommends testing people in certain high-risk groups more frequently. ; Testing, diagnosis, and timely treatment can prevent hepatitis C complications and interrupt transmission.
Autoimmune hepatitis (AIH) is a relatively rare chronic, autoimmune disorder of the liver with rising prevalence in the United States and globally. Since its identification in the mid-twentieth century, glucocorticoids and azathioprine have been the mainstay treatments for patients with AIH—but why? · Patients with AIH range from being asymptomatic with abnormal liver tests (typically with hepatocellular injury evidenced by elevations in aspartate aminotransferase [AST] and alanine aminotran...
2019년에 발표된 AASLD practice guideline 에서 C형간염의 검사(test)와 관리(management)는 선별검사 대상자의 연령을 18세로 조정한 것 외에는 눈에 띄는 변화가 없지만 치료(treatment)를 단순화했다는 점이 특징이다. 이는 DAA 제제의 도입으로 치료 성공률이 높아진 현 시점에서는 치료를 받지 않은 환자들을 찾아내어 진단률을 높이는 것이 중요하며, 진단 시에는 pangenotype약제를 이용하여 치료 방법을 단순화함으로써 더 많은 ...
Exposure to hepatitis viruses has long been recognized as an occupational risk for health care personnel (HCP). HCPs might be exposed to blood or other body fluids, by injury from a used needle, or from a splash of blood or body fluids into the eye or mouth while caring for a patient. This guidance provides CDC recommendations for laboratory testing and follow-up of HCPs who have potentially been exposed to hepatitis C virus (HCV) through an exposure to blood or other infectious body fluid.
As trainees, we are well versed in screening for hepatitis B (HBV) and hepatitis C (HCV). However, few of us have experience with hepatitis delta (HDV). This post will offer a quick history and review of hepatitis D and remind us about why screening is so important! · HDV was first reported in humans in Italy in 1977 by Rizzetto in a cohort of Italian patients with HBV presenting with severe hepatitis. A new antigen, called the delta antigen, was detected by direct immunofluorescence in the li...
발행년도: 2022, 제목: BCLC 병기 체계 2022 개정 ; 발행년도: 2021, 제목: 가이드라인 업데이트 [대한간학회 비알코올 지방간질환 진료 가이드라인 2021] ; 발행년도: 2020, 제목: 가이드라인 업데이트 [AASLD practice guidelines : Autoimmune hepatitis Guidance 2019 Update ; 발행년도: 2020, 제목: 가이드라인 업데이트 [AASLD practice guidelines : Hepatitis C Guidance 2019 Update] ; 발행년도: 2019, 제목: 가이드라인 업데이트 [EASL clinical practice guidelines: Drug-induced liver injury (DILI)] ; 발행년도: 2019, 제목: 2019 대한간학회 간경변증 진료 가이드라인 [치료와 재발 예방 관련 사항 발췌] ; 발행년도: 2019, 제목: 2018 대한간학회 만성 B형간염 진료 가이드라인 [치료 관련 권고 사항 발췌]
What is HBV reactivation? · In patients with chronic HBV (defined as HBsAg+ for at least 6 months and measurable HBV DNA in the blood), reactivation is defined by an increase in HBV DNA above baseline whereas in patients with resolved HBV (defined by HBsAg - and anti-HBc+), reactivation is defined by either appearance of HBV DNA in the blood or conversion to HbsAg + state (i.e. reverse seroconversion) (Table 1). Table 1 - Guideline Specific Definition of HBV Reactivation · Taken from: Terrau...
Recommended DAA Treatment Regimens: The recommendation on how to choose an anti-HCV regimen was revised; choosing a regimen is based on findings from the pretreatment assessment and history of HCV treatment and not HCV genotype. Accordingly, the tables of recommended treatment regimens were revised. Post-Treatment Care: A recommendation was added for clinicians to refer patients with cirrhosis to a liver disease specialist for continued care. Note: The NYSDOH AI guideline Treatment of Chronic HCV with Direct-Acting Antivirals (July 2017 through ...