Selling Stem Cells in the USA: Assessing the Direct-to-Consumer Industry

1Center for Bioethics, School of Public Health, and College of Pharmacy, University of... We used key words and phrases such as ‘‘stem cell treatment’’ and ‘‘stem cell ther...

Phase I clinical trial of intracerebroventricular transplantation of allogeneic - Cell Press

Leone, Gelati, and colleagues assessed the intracerebroventricular injection (ICVI) of allogeneic human neural stem/progenitor cells (hNSCs) for the treatment of progressive multiple sclerosis. The...

Stem Cells | The ALS Association

Stem cells have the ability to divide for indefinite periods in culture and give rise to multiple specialized cell types. They can develop into blood, neurons, bone, muscle, skin and other cell typ...

KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury: C....

Highlights ; · Mechanically injured organoids display hallmark features of traumatic brain injury ; · TDP-43 dysfunction is a key driver of acute injury and is enhanced in ALS/FTD ; · A CRISPRi screen identifies KCNJ2 inhibition as a therapeutic target in vitro ; · Kcnj2 knockdown in mice reduces TDP-43 pathology and is protective against brain injury

SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS: Cell Stem Cell

Highlights ; · A phenotypic screen identifies SYF2 suppression as a therapeutic target for ALS ; · SYF2 suppression alleviates disease in a diverse collection of iPSC models of ALS ; · SYF2 suppression slows TDP-43 nuclear export, reduces aggregation, and improves splicing ; · Syf2 suppression mitigates motor deficits and neuropathology in a mouse model of ALS

Selling Stem Cells in the USA: Assessing the Direct-to-Consumer Industry: Cell Stem Cell

However, it was not our intention to make evaluative statements concerning whether particular companies are marketing stem cell interventions in compliance with federal and state regulations as well as contemporary ethical standards for medical practice. Nor was it our intention to make ethical or lega ...

Promising stem-cell based drug for treatment of ALS receives patent - The Jerusalem Post

for the promising new drug AstroRx to treat Amyotrophic Lateral Sclerosis (ALS). The new medication uses embryonic stem... astrocyte cell populations in the disease's treatment and slowing...

Taking on the Elephant in the Tissue Culture Room: iPSC Modeling for Sporadic ALS: Cell Stem Cell

References ; Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial ; A post hoc analysis of subgroup outcomes and creatinine in the phase III clinical trial (EMPOWER) of dexpramipexole in ALS ; Comparative transcriptomics in human and mouse ; The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis

Stem-cell therapy

The doses are stored frozen until needed.[10] The FDA has approved five hematopoietic stem-cell products derived from umbilical cord blood, for the treatment of blood and immunological...

Phase 1/2a clinical trial in ALS with ropinirole, a drug candidate identified by - Cell Press

3 Induced pluripotent stem cell (iPSC)-derived motor neurons (MNs) from ALS patients can overcome these limitations for drug... for Parkinson’s disease, was identified as a treatment...