Comprehensive peripheral blood immunoprofiling reveals five immunotypes with immunotherapy response chara....

Dyikanov et al. developed a machine learning platform that uses a simple blood test to reveal cellular compositions reflective of a person’s immune system. These compositions, delineated into five...

Integrated transcriptomics of human blood vessels defines a spatially controlled niche for early mesenchy....

Highlights ; Integrated transcriptomics delineates the topography of human blood vessels ; CD201-expressing progenitors are spatially restricted to the outer adventitia ; progenitors are primitive with higher stem-like activity ; Wnt signaling inhibitor DACT2 controls the functional role of CD201 progenitors

Accurate age prediction from blood using a small set of DNA methylation sites and a cohort-based machine ....

Motivation : Epigenetic clocks predict age from DNA methylation and are a valuable tool in the research of human aging, with additional applications in forensic profiling, disease monitoring, and lifespan prediction. Most existing epigenetic clocks are based on linear models and require hundreds of methylation sites. However, non-linear patterns of methylation changes across aging are observed for many CpG sites. Here, we present a compact epigenetic clock for blood, which outperforms state-of-t...

Identification of biomarkers and potential therapeutic targets for pancreatic ca - Cell Press

Short Article|Online Now, 100561 Identification of biomarkers and potential therapeutic... Aberrant alterations in the blood proteome might serve as biomarkers to facilitate early detection...

iNKT Cell Identification Protocol | Thermo Fisher Scientific - KR

This protocol describes methods to identify invariant natural killer T (iNKT) cells from blood samples.

Identification of activity-based biomarkers for early-stage pancreatic tumors in

in blood •Candidate activity-based biomarkers of early-stage... Activity-based screening using blood samples revealed altered single-molecule activity profiles of CD13 and DPP4 in blood...

Hormonal gatekeeping via the blood-brain barrier governs caste-specific behavior in ants

Highlights ; · Single-cell RNA-seq identifies hormone-degrading esterase CfJhe localized to ant BBB ; · CfJhe expression is high in non-foraging Major-worker BBB cells leading to low JH3 ; · Ectopic expression of CfJhe in fly leads to loss of foraging-like behavior ; · KD of CfJhe leads to acquisition of foraging in Major workers

Blood transfusion

Historically, red blood cell transfusion was considered when the hemoglobin level fell below 100g/L or hematocrit fell below 30%. [3][4] Because each unit of blood given carries risks, a...

Simultaneous high throughput genotyping of 36 blood group systems using NGS based on probe capture techno....

the identification of red blood cell antigens across multiple blood group systems. 2. Results 2.1. ABO blood group system analysis using NGS Among the 199 blood donors, the serological...

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Meta

unpurified blood cell preparations (for review, see Yu et al., 2011). The fact that CTCs are extremely rare, even in patients with advanced metastatic cancers (esti- mated at one CTC...