Instructors: Randy Ching & Bil Ledoux · Office Hours: By appointment... · Contact Info: Randy Ching, Ph.D. Email: rc@uw... Phone: 206-625-0633 Bil Ledoux, Ph.D. Email: wrledoux@uw... Phone: 206-768-5347
Textbook is highly recommended but not required. Mechanics of Materials, Brief Edition, by James M. Gere. (c) 2011. SI units version is recommended. Other editions of this text will also suffice, but other texts by the same name by other authors will not. Unsure whether to buy the text? The first 6 weeks of class closely follow the text, while the last 4 weeks cover more biological topics not addressed in Gere. Comments from students last year were split about 50/50; half gave comments like "I b...
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배울 내용 ; The Interlink Between Mechanical Engineering and HVAC Engineering ; HVAC Design Principles that Mechanical Engineers Should be equipped with ; HVAC Key Terminology that Mechanical Engineers Should be Familiar With
Medications, corticosteroids , dilantin and other anticonvulsants, gonadotropin releasing hormone agonists, loop diuretics, methotrexate, excess thyroid, heparin, depo-medroxyprogesterone acetate, anti-neoplastic agents, cyclosporin, proton-pump inhibitors, selective serotonin reuptake inhibitors , aromatase inhibitors ; Hereditary skeletal/connective tissue diseases, osteogenesis imperfecta, rickets , hypophosphatasia, Marfan's syndrome, pseudoglioma. ; Endocrine and metabolic, HYPOGONADISM, prolactinoma, hypopituitarism, hyperparathyroidism, hyperthyroidism, Cushing syndrome, acidosis, diabetes type I and type II, androgen insensitivity, Gaucher's disease, hemochromatosis ; Gastro-intestinal, Celiac sprue , malabsorption, malnutrition, inflammatory bowel disease, chronic hepatic disease ; Rheumatologic diseases, systemic lupus, ankylosing spondylitis, rheumatoid arthritis ; Marrow diseases, myeloma, mastocytosis, thalassemia, leukemia ; Renal disease, Chronic Kidney Disease , renal tubular acidosis, Hypercalciuria ; Neurologic diseases, spinal cord injury, stroke, Parkinson's disease, history of polio ; Psychiatric diseases, alcoholism, depression, anorexia nervosa ; Pulmonary diseases, chronic obstructive pulmonary disease, cystic fibrosis ; Other, organ transplantation , lactation , AIDS, transient regional osteoporosis, any disease that causes serious weight loss or prolonged bedrest ; Fractures not caused by osteoporosis, severe trauma, cancer metastasis to the bone, Paget's disease, tuberculosis (Pott's disease), avascular necrosis, fibrous dysplasia, osteomalacia, repetitive injury (March fractures)
In addition to bone porosity, the bone strength is determined by the trabecular microstructure. Perforations of individual trabecula occur when resorption cavities are too deep. This, too...
Phase: Origination, Factors: (+) PTH, IGF, IL-1, IL-6, PGE, calcitriol, TNF, NO (-) estrogen ; Phase: Osteoclast recruitment, Factors: (+) RANK-ligand, M-CSF (-) osteoprotegerin (OPG), GM-CSF click to see movie ; Phase: Resorption, Factors: (+) Integrins, some interleukins, acidosis, vitamin A (-) estrogen, calcitonin, interferon, TGF, other interleukins, sFRP-1 ; Phase: Osteoblast recruitment, Factors: (+) Wnt, BMPs, IGF, FGFs, PDGFs, CSF, PTH, calcitriol, Runx2, GST-RANK-Ligand, TGF-beta (-) ? leptin ; Phase: Osteoid formation, Factors: (+) TGF-beta, BMPs, IGF (-) FGFs, PDGFs, glucocorticoids ; Phase: Mineralization, Factors: (+) calcium, phosphate (-) pyrophosphate ; Phase: Mineral maturation, Factors: Other ions ; Phase: Quiescence, Factors:
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